61 research outputs found
First Results from SPARO: Evidence for Large-Scale Toroidal Magnetic Fields in the Galactic Center
We have observed the linear polarization of 450 micron continuum emission
from the Galactic center, using a new polarimetric detector system that is
operated on a 2 m telescope at the South Pole. The resulting polarization map
extends ~ 170 pc along the Galactic plane and ~ 30 pc in Galactic latitude, and
thus covers a significant fraction of the central molecular zone. Our map shows
that this region is permeated by large-scale toroidal magnetic fields. We
consider our results together with radio observations that show evidence for
poloidal fields in the Galactic center, and with Faraday rotation observations.
We compare all of these observations with the predictions of a magnetodynamic
model for the Galactic center that was proposed in order to explain the
Galactic Center Radio Lobe as a magnetically driven gas outflow. We conclude
that the observations are basically consistent with the model.Comment: 11 pages, 2 figures, 1 table, submitted to ApJ Let
Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children With Relapsed or Refractory Pediatric Sarcomas
Given the poor prognosis of pediatric patients with relapsed or refractory sarcomas, discovery and implementation of innovative approaches and tools to guide therapy are urgent needs. This retrospective pilot study evaluated the impact of relapse and refractory therapies aligned with molecular characterization of biopsies collected at the time of primary diagnosis
IODNE: An integrated optimization method for identifying the deregulated subnetwork for precision medicine in cancer
Subnetwork analysis can explore complex patterns of entire molecular pathways for the purpose of drug target identification. In this article, the gene expression profiles of a cohort of patients with breast cancer are integrated with protein-protein interaction (PPI) networks using, simultaneously, both edge scoring and node scoring. A novel optimization algorithm, integrated optimization method to identify deregulated subnetwork (IODNE), is developed to search for the optimal dysregulated subnetwork of the merged gene and protein network. IODNE is applied to select subnetworks for Luminal-A breast cancer from The Cancer Genome Atlas (TCGA) data. A large fraction of cancer-related genes and the well-known clinical targets, ER1/PR and HER2, are found by IODNE. This validates the utility of IODNE. When applying IODNE to the triple-negative breast cancer (TNBC) subtype data, we identified subnetworks that contain genes such as ERBB2, HRAS, PGR, CAD, POLE, and SLC2A1
Observations of the Near-infrared Spectrum of the Zodiacal Light with CIBER
Interplanetary dust (IPD) scatters solar radiation which results in the zodiacal light that dominates the celestial diffuse brightness at optical and near-infrared wavelengths. Both asteroid collisions and cometary ejections produce the IPD, but the relative contribution from these two sources is still unknown. The low resolution spectrometer (LRS) onboard the Cosmic Infrared Background ExpeRiment (CIBER) observed the astrophysical sky spectrum between 0.75 and 2.1 ÎĽm over a wide range of ecliptic latitude. The resulting zodiacal light spectrum is redder than the solar spectrum, and shows a broad absorption feature, previously unreported, at approximately 0.9 ÎĽm, suggesting the existence of silicates in the IPD material. The spectral shape of the zodiacal light is isotropic at all ecliptic latitudes within the measurement error. The zodiacal light spectrum, including the extended wavelength range to 2.5 ÎĽm using Infrared Telescope in Space (IRTS) data, is qualitatively similar to the reflectance of S-type asteroids. This result can be explained by the proximity of S-type asteroidal dust to Earth's orbit, and the relatively high albedo of asteroidal dust compared with cometary dust
The Cosmic Infrared Background Experiment (CIBER): Instrumentation and First Results
Ultraviolet emission from the first generation of stars in the Universe ionized the intergalactic medium in a process which was completed by z similar to 6; the wavelength of these photons has been redshifted by (1 + z) into the near infrared today and can be measured using instruments situated above the Earth's atmosphere. First flying in February 2009, the Cosmic Infrared Background ExpeRiment (CIBER) comprises four instruments housed in a single reusable sounding rocket borne payload. CIBER will measure spatial anisotropies in the extragalactic IR background caused by cosmological structure from the epoch of reionization using two broadband imaging instruments, make a detailed characterization of the spectral shape of the IR background using a low resolution spectrometer, and measure the absolute brightness of the Zodiacal light foreground with a high resolution spectrometer in each of our six science fields. The scientific motivation for CIBER and details of its first and second flight instrumentation will be discussed. First flight results on the color of the zodiacal light around 1 mu m and plans for the future will also be presented
The Cosmic Infrared Background Experiment (CIBER): A Sounding Rocket Payload to Study the Near Infrared Extragalactic Background Light
The Cosmic Infrared Background Experiment (CIBER) is a suite of four instruments designed to study the near infrared (IR) background light from above the Earth's atmosphere. The instrument package comprises two imaging telescopes designed to characterize spatial anisotropy in the extragalactic IR background caused by cosmological structure during the epoch of reionization, a low resolution spectrometer to measure the absolute spectrum of the extragalactic IR background, and a narrow band spectrometer optimized to measure the absolute brightness of the Zodiacal light foreground. In this paper we describe the design and characterization of the CIBER payload. The detailed mechanical, cryogenic, and electrical design of the system are presented, including all system components common to the four instruments. We present the methods and equipment used to characterize the instruments before and after flight, and give a detailed description of CIBER's flight profile and configurations. CIBER is designed to be recoverable and has flown twice, with modifications to the payload having been informed by analysis of the first flight data. All four instruments performed to specifications during the second flight, and the scientific data from this flight are currently being analyzed
MAXIPOL: Cosmic Microwave Background Polarimetry Using a Rotating Half-Wave Plate
We discuss MAXIPOL, a bolometric balloon-borne experiment designed to measure
the E-mode polarization of the cosmic microwave background radiation (CMB).
MAXIPOL is the first bolometric CMB experiment to observe the sky using rapid
polarization modulation. To build MAXIPOL, the CMB temperature anisotropy
experiment MAXIMA was retrofitted with a rotating half-wave plate and a
stationary analyzer. We describe the instrument, the observations, the
calibration and the reduction of data collected with twelve polarimeters
operating at 140 GHz and with a FWHM beam size of 10 arcmin. We present maps of
the Q and U Stokes parameters of an 8 deg^2 region of the sky near the star
Beta Ursae Minoris. The power spectra computed from these maps give weak
evidence for an EE signal. The maximum-likelihood amplitude of
l(l+1)C^{EE}_{l}/(2 pi) is 55_{-45}^{+51} uK^2 (68%), and the likelihood
function is asymmetric and skewed positive such that with a uniform prior the
probability that the amplitude is positive is 96%. This result is consistent
with the expected concordance LCDM amplitude of 14 uK^2. The maximum likelihood
amplitudes for l(l+1)C^{BB}_{l}/(2 pi) and are
-31_{-19}^{+31} and 18_{-34}^{+27} uK^2 (68%), respectively, which are
consistent with zero. All of the results are for one bin in the range 151 < l <
693. Tests revealed no residual systematic errors in the time or map domain. A
comprehensive discussion of the analysis of the data is presented in a
companion paper.Comment: 19 pages, 11 figures, 2 tables, submitted to Ap
Low serum albumin levels prior to pediatric allogeneic HCT are associated with increased need for critical care interventions and increased 6-month mortality
Poor nutritional status in HCT patients is a negative prognostic factor. There are no pediatric studies evaluating albumin levels prior to HCT and need for critical care interventions. We hypothesized that pediatric patients with low albumin levels, routinely measured 30 days (±10 days) prior to allogeneic HCT, have a higher risk of critical care interventions in the post-transplant period. We performed a 5-year retrospective study of pediatric patients who underwent allogeneic HCT for any indication. Patients were categorized based on albumin level. Hypoalbuminemia was defined as <3.1 g/dL. A total of 73 patients were included, with a median age of 7.4 years (IQR 3.3, 13.2). Patients with hypoalbuminemia had higher needs for critical care interventions including non-invasive ventilation (44% vs 8%, P=.01), mechanical ventilation (67% vs 17%, P<.01), and vasoactive therapy (56% vs 16%, P=.01). Patients with hypoalbuminemia also had a higher 6-month mortality (56% vs 17%, P=.02). Our data demonstrate that children undergoing allogeneic HCT with hypoalbuminemia in the pretransplant period are more likely to require critical care interventions and have higher 6-month mortality. These findings identify an at-risk population in which nutritional improvements may be instituted prior to HCT in hopes of improving outcomes
The EBEX Experiment
EBEX is a balloon-borne polarimeter designed to measure the intensity and
polarization of the cosmic microwave background radiation. The measurements
would probe the inflationary epoch that took place shortly after the big bang
and would significantly improve constraints on the values of several
cosmological parameters. EBEX is unique in its broad frequency coverage and in
its ability to provide critical information about the level of polarized
Galactic foregrounds which will be necessary for all future CMB polarization
experiments. EBEX consists of a 1.5 m Dragone-type telescope that provides a
resolution of less than 8 arcminutes over four focal planes each of 4 degree
diffraction limited field of view at frequencies up to 450 GHz. The experiment
is designed to accommodate 330 transition edge bolometric detectors per focal
plane, for a total of up to 1320 detectors. EBEX will operate with frequency
bands centered at 150, 250, 350, and 450 GHz. Polarimetry is achieved with a
rotating achromatic half-wave plate. EBEX is currently in the design and
construction phase, and first light is scheduled for 2008.Comment: 13 pages, 10 figures. Figure 1 is changed from the one which appeared
in the Proceedings of the SPI
The Robinson Gravitational Wave Background Telescope (BICEP): a bolometric large angular scale CMB polarimeter
The Robinson Telescope (BICEP) is a ground-based millimeter-wave bolometric
array designed to study the polarization of the cosmic microwave background
radiation (CMB) and galactic foreground emission. Such measurements probe the
energy scale of the inflationary epoch, tighten constraints on cosmological
parameters, and verify our current understanding of CMB physics. Robinson
consists of a 250-mm aperture refractive telescope that provides an
instantaneous field-of-view of 17 degrees with angular resolution of 55 and 37
arcminutes at 100 GHz and 150 GHz, respectively. Forty-nine pair of
polarization-sensitive bolometers are cooled to 250 mK using a 4He/3He/3He
sorption fridge system, and coupled to incoming radiation via corrugated feed
horns. The all-refractive optics is cooled to 4 K to minimize polarization
systematics and instrument loading. The fully steerable 3-axis mount is capable
of continuous boresight rotation or azimuth scanning at speeds up to 5 deg/s.
Robinson has begun its first season of observation at the South Pole. Given the
measured performance of the instrument along with the excellent observing
environment, Robinson will measure the E-mode polarization with high
sensitivity, and probe for the B-modes to unprecedented depths. In this paper
we discuss aspects of the instrument design and their scientific motivations,
scanning and operational strategies, and the results of initial testing and
observations.Comment: 18 pages, 11 figures. To appear in Millimeter and Submillimeter
Detectors and Instrumentation for Astronomy III, Proceedings of SPIE, 6275,
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